Applications of physiologic pharmacokinetic modeling in carcinogenic risk assessment.

Applications of physiologic pharmacokinetic modeling in carcinogenic risk assessment.

The use of physiologically based pharmacokinetic (PBPK) models has been proposed as a means of estimating the dose of the reactive metabolites of carcinogenic xenobiotics reaching target tissues, thereby affording an opportunity to base estimates of potential cancer risk on tissue dose rather than external levels of exposure. In this article, we demonstrate how a PBPK model can be constructed b...

Carcinogenic and Non-Carcinogenic Risk Assessment of Some Heavy Metals Due to Consumption of Raisin Produced in Malayer City

Carcinogenic and Non-Carcinogenic Risk Assessment of Some Heavy Metals Due to Consumption of Raisin Produced in Malayer City Eisa solgi1*, Tarokh khodadadi2 1Associate Professor, Department of Environment, Faculty of Natural Resources and Environment,  Malayer University 2Ph.D. Student of Environmental Pollution, Faculty of Natural Resources and Environment, Malayer University Abstract In...

Implications of pharmacokinetic modeling in risk assessment analysis.

Physiologic pharmacokinetic models are a useful interface between exposure models and risk assessment models by providing a means to estimate tissue concentrations of reactive chemical species at the site of action. The models utilize numerous parameters that can be characterized as anatomical, such as body size or tissue volume; physiological, such as tissue blood perfusion rates, clearances, ...

Models for carcinogenic risk assessment.

approach is the recognition that the response to a carcinogenic agent depends on the rate of exposure. For the radioactive agents the priority for the study of the so-called dose-rate effects appears to belong to Upton (3). A review (4) indicates that important dose-rate effects exist also for certain chemical carcinogens. Another item that I miss in Comnfield's approach is the phenomenon of sy...

Models for carcinogenic risk assessment.